Anti-FARSB monoclonal antibody (DMABT-H13718)

Mouse anti-Human FARSB monoclonal antibody for WB, IHC, ELISA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Clone
3G22
Species Reactivity
Human
Immunogen
FARSLB (NP_005678, 234 a.a. ~452a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Target


Alternative Names
FARSB; phenylalanyl-tRNA synthetase, beta subunit; FARSLB, phenylalanyl tRNA synthetase like, beta subunit; phenylalanine--tRNA ligase beta subunit; FRSB; PheHB
Entrez Gene ID
UniProt ID

Product Background


Gene summary
FARSB (Phenylalanyl-TRNA Synthetase Beta Subunit) is a Protein Coding gene. Among its related pathways are Gene Expression and tRNA Aminoacylation. GO annotations related to this gene include RNA binding and magnesium ion binding. An important paralog of this gene is LRRC47. This gene encodes a highly conserved enzyme that belongs to the aminoacyl-tRNA synthetase class IIc subfamily. This enzyme comprises the regulatory beta subunits that form a tetramer with two catalytic alpha subunits. In the presence of ATP, this tetramer is responsible for attaching L-phenylalanine to the terminal adenosine of the appropriate tRNA. A pseudogene located on chromosome 10 has been identified. Alternative splicing results in multiple transcript variants.
Antigen Description
Protein Symbol:Q9NSD9-SYFB_HUMANRecommended name:Phenylalanine--tRNA ligase beta subunitProtein Accession:Q9NSD9Secondary Accessions:B4DFM0O95708Q4ZFX1Q57ZJ5Q9NZZ6Phenylalanyl-tRNA synthetase beta chain is an enzyme that in humans is encoded by the FARSB gene. 0The function about FARSB antigen include ATP binding; RNA binding; ligase activity; magnesium ion binding; nucleotide binding; phenylalanine-tRNA ligase activity.
Pathway
Aminoacyl-tRNA biosynthesis, organism-specific biosystem; Aminoacyl-tRNA biosynthesis, conserved biosystem; Aminoacyl-tRNA biosynthesis, eukaryotes, organism-specific biosystem; Aminoacyl-tRNA biosynthesis, eukaryotes, conserved biosystem; Cytosolic tRNA aminoacylation, organism-specific biosystem; Gene Expression, organism-specific biosystem; tRNA Aminoacylation, organism-specific biosystem.

Citations


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References


Moor, NA; Ankilova, VN; et al. Determination of tRNA(Phe) nucleotides contacting the subunits of Thermus thermophilus phenylalanyl-tRNA synthetase by photoaffinity crosslinking. BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION 1518:226-236(2001).
Moor, N; Lavrik, O; et al. Prokaryotic and eukaryotic tetrameric phenylalanyl-tRNA synthetases display conservation of the binding mode of the tRNA(Phe) CCA end. BIOCHEMISTRY 42:10697-10708(2003).

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