Transcription of protein-coding genes can be reconstituted on naked DNA with only the general transcription factors and RNA polymerase II. However, this minimal system cannot transcribe DNA packaged into chromatin, indicating that accessory factors may facilitate access to DNA. One such factor, FACT (facilitates chromatin transcription), interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT is composed of an 80 kDa subunit and a 140 kDa subunit; this gene encodes the 140 kDa subunit. [provided by RefSeq, Feb 2009]
Function
GTP binding;
Synonyms
SUPT16H; suppressor of Ty 16 homolog (S. cerevisiae); suppressor of Ty (S.cerevisiae) 16 homolog; FACT complex subunit SPT16; CDC68; facilitates chromatin remodeling 140 kDa subunit; FACT; FACTP140; FLJ10857; FLJ14010; SPT16/CDC68; hSPT16; FACT 140 kDa subunit; facilitates chromatin transcription complex subunit SPT16; chromatin-specific transcription elongation factor 140 kDa subunit; FLJ34357;
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