The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene. [provided by RefSeq, Jul 2008]
Function
actin filament binding; cell adhesion molecule binding; poly(A) RNA binding; protein binding; protein domain specific binding;
Synonyms
EZR; ezrin; CVL; CVIL; VIL2; HEL-S-105; p81; villin-2; cytovillin 2; villin 2 (ezrin); epididymis secretory protein Li 105;
Citations
Publication ()
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