Anti-EN1 monoclonal antibody (DMABT-H13649)

Mouse anti-Human EN1 monoclonal antibody for WB, IHC, sELISA, ELISA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Clone
4I3
Species Reactivity
Human
Immunogen
EN1 (NP_001417, 266 a.a. ~ 392 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Target


Alternative Names
EN1; engrailed homeobox 1; homeobox protein engrailed-1; hu-En-1; engrailed homolog 1; homeobox protein en-1
Entrez Gene ID
UniProt ID

Product Background


Gene summary
EN1 (Engrailed Homeobox 1) is a Protein Coding gene. Diseases associated with EN1 include tyrosinemia, type iii and salivary gland adenoid cystic carcinoma. Among its related pathways are Neural Stem Cell Differentiation Pathways and Lineage-specific Markers and SIDS Susceptibility Pathways. GO annotations related to this gene include sequence-specific DNA binding and transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding. An important paralog of this gene is EN2. Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system.
Antigen Description
Protein Symbol:Q05925-HME1_HUMANRecommended name:Homeobox protein engrailed-1Protein Accession:Q05925Secondary Accessions:Q4ZG44Homeobox protein engrailed-1 is a protein that in humans is encoded by the EN1 gene. Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the engrailed (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system.
Pathway
SIDS Susceptibility Pathways, organism-specific biosystem.

Citations


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References


Yue, FM; Cui, L; et al. Induction of midbrain dopaminergic neurons from primate embryonic stem cells by coculture with Sertoli cells. STEM CELLS 24:1695-1706(2006).
Abzhanov, A; Kaufman, TC; et al. Evolution of distinct expression patterns for engrailed paralogues in higher crustaceans (Malacostraca). DEVELOPMENT GENES AND EVOLUTION 210:493-506(2000).

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