Human EIF2AK1 peptide

Specificity

Expressed predominantly in erythroid cells. At much lower levels, expressed in hepatocytes (at protein level).

Nature

Synthetic

Tag/Conjugate

Unconjugated

Format

Liquid

Preservative

None

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. Information available upon request.

Gene ID

27102

UniProt ID

Q9BQI3

Antigen Description

The protein encoded by this gene acts at the level of translation initiation to downregulate protein synthesis in response to stress. The encoded protein is a kinase that can be inactivated by hemin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

Function

ATP binding; eukaryotic translation initiation factor 2alpha kinase activity; heme binding; protein homodimerization activity;

Synonyms

EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1; HCR; HRI; heme-regulated inhibitor; heme-regulated repressor; heme-controlled repressor; heme sensitive initiation factor 2a kinase; heme regulated initiation factor 2 alpha kinase; heme-regulated initiation factor 2-alpha kinase; hemin-sensitive initiation factor 2-alpha kinase; heme-regulated eukaryotic initiation factor eIF-2-alpha kinase;