Expressed predominantly in erythroid cells. At much lower levels, expressed in hepatocytes (at protein level).
Nature
Synthetic
Tag/Conjugate
Unconjugated
SequenceSimilarities
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.Contains 2 HRM (heme regulatory motif) repeats.Contains 1 protein kinase domain.
Format
Liquid
Preservative
None
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. Information available upon request.
The protein encoded by this gene acts at the level of translation initiation to downregulate protein synthesis in response to stress. The encoded protein is a kinase that can be inactivated by hemin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Function
ATP binding; eukaryotic translation initiation factor 2alpha kinase activity; heme binding; protein homodimerization activity;
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