EBV Nuclear Antigen (DAG-P2288)

EBV Nuclear Antigen (aa 1 - 352), recombinant protein from E. coli

Product Overview
EBV Nuclear Antigen full length protein
Nature
Recombinant
Tag/Conjugate
Unconjugated
Molecular Weight
63 kDa including tags
Cellular Localization
Nuclear. Free in the nucleoplasm, somewhat associated with the chromatin and hardly, if at all associated with the nuclear matrix.
Procedure
None
Purity
>95% by SDS-PAGE .
Format
Liquid
Buffer
pH: 8.00Constituents: 58% Phosphate Buffer, 36% Urea, 5.8% Sodium chloride
Preservative
None
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. pH: 8.00Constituents: 58% Phosphate Buffer, 36% Urea, 5.8% Sodium chloride
Introduction
The Epstein–Barr virus (EBV), also called human herpesvirus 4 (HHV-4), is a virus of the herpes family, and is one of the most common viruses in humans.
Antigen Description
Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA1) is the one EBV antigen that is expressed in all EBV associated malignancies. It has long been thought to go undetected by the cell mediated immune system. However, recent studies show that EBNA1 can be presented to both CD4+ and CD8+ T cells, making it a potential new target for immunotherapy of EBV related cancers.
Keywords
EBNA1; EBV nuclear antigen 1; Epstein Barr nuclear antigen 1; Epstein Barr virus; HHV4; Human Herpesvirus 4; EBV Nuclear Antigen

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References


Cigni, A; Soro, G; et al. A case of adult-onset tubulointerstitial nephritis and uveitis ("TINU syndrome") associated with sacroileitis and Epstein-Barr virus infection with good spontaneous outcome. AMERICAN JOURNAL OF KIDNEY DISEASES 42:-(2003).
Gartner, BC; Hess, RD; et al. Evaluation of four commercially available Epstein-Barr virus enzyme immunoassays with an immunofluorescence assay as the reference method. CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY 10:78-82(2003).

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