EBV LMP2 Tetramer (DAG3111)

Product Overview
EBV LMP2 Tetramer
Nature
Native
Tag/Conjugate
Unconjugated
Procedure
None
Concentration
50ug per 100ul
Preservative
None
Storage
2-8°C short term, -20°C long term
Introduction
Epstein–Barr virus (EBV) is a member of the herpesvirus family and one of the most common human viruses. Most people become infected with EBV during their lives. Primary infections usually results in infectious mononucleosis (glandular fever) but the virus can also lay dormant in B lymphocytes and when reactivated become associated with more serious disease such as Burkitt's lymphoma, nasopharyngeal carcinoma and Hodgkin's disease. EBV latently infects B lymphocytes. Infected B cells express EBV nuclear antigens and latent proteins LMP1, LMP2A and LMP2B. LMP2A forms aggregates in the plasma membranes of B lymphocytes, where it functions as a negative regulator of the Src and Syk protein tyrosine kinases. Studies show that LMP2A blocks B-cell receptor (BCR) signal transduction in EBV immortalized B cells in vitro and may play an important role in maintaining a latent EBV infection within the peripheral blood B cells of infected individuals. Varicella-zoster virus (VZV or HHV3) is a member of the genus Varicellovirus in the Alphaherpesvirinae subfamily of the Herpesviridae. It is the causative agent of chicken pox (varicella) in children, after which it establishes latency in the sensory ganglia with the potential to reactivate at a later time to cause shingles (zoster). This is an extremely stable virus. The genome is comprised of ~125 kb of linear double-stranded DNA containing approximately 71 open reading frames (ORFs). The viral structure is similar to that of other alphaherpesviruses, consisting of two unique regions, unique long and unique short, each flanked by inverted repeats; short repeats termed terminal repeat long and internal repeat long border the unique long region, while larger repeats termed terminal repeat short (TRS) and internal repeat short (IRS) border the unique short region. Varicella-zoster virus (VZV) interacts with cell surface heparan sulfate proteoglycans during virus attachment.
Antigen Description
EBV latent membrane protein 2 (LMP-2) refers to two viral proteins associated with Epstein-Barr virus.LMP-2A/LMP-2B are transmembrane proteins that act to block tyrosine kinase signaling. It is believed that they act to inhibit activation of the viral ly
Keywords
VZV Ag, LMP-2; Varicella-Zoster Virus LMP-2; Glycoproteins; Varicella zoster virus; VZV; Human herpes virus 3; HHV 3; HHV3; Human herpes virus 3; Membrane glycoprotein LMP-2; Varicella Zoster Virus; VZV LMP-2; Herpesviridae; Varicellovirus; EBV latent mem

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