Human DCN peptide

Name: Human DCN peptide
SKU: DAG-P0420
Rating: 5 (1 reviews)

Regulatory status: For research use only, not for use in diagnostic procedures.

COA

SDS

Datasheet

Summary

Nature

Synthetic

Tag/Conjugate

Unconjugated

SequenceSimilarities

DCN peptide is a synthetic peptide corresponding to the internal region of DCN.

Purity

> 95 % by SDS-PAGE.

Format

Lyophilized

Preservative

None

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. Information available upon request.

Reconstitution

DCN peptide is supplied as 1mg of dried peptide. When the peptide is reconstituted in 1 mL strile water, the concentration will be 1 mg/mL.

Introduction

The protein encoded by this gene is a small cellular or pericellular matrix proteoglycan that is closely related in structure to biglycan protein. The encoded protein and biglycan are thought to be the result of a gene duplication. This protein is a component of connective tissue, binds to type I collagen fibrils, and plays a role in matrix assembly. It contains one attached glycosaminoglycan chain. This protein is capable of suppressing the growth of various tumor cell lines. There are multiple alternatively spliced transcript variants known for this gene. This gene is a candidate gene for Marfan syndrome. [provided by RefSeq, Jul 2008]

Entrez Gene ID

1634

Synonyms

DCN; decorin; CSCD; PG40; PGII; PGS2; DSPG2; SLRR1B; PG-S2; bone proteoglycan II; decorin proteoglycan; proteoglycan core protein; small leucine-rich protein 1B; dermatan sulphate proteoglycans II;

Citations

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Documents

pdf COA

pdf SDS

pdf Datasheet

QA & Reviews

Customer Reviews

References

A novel water-soluble fluorescent probe with ultra-sensitivity over a wider pH range and its application for differentiating cancer cells from normal cells

ANALYST

Authors: Li, Zilu; Yu, Chen; Chen, Yanan; Zhuang, Zihan; Tian, Bin; Liu, Caiyun; Jia, Pan; Zhu, Hanchuang; Sheng, Wenlong; Zhu, Baocun

Abstract

A novel pH-sensitive fluorescent probe has been designed and synthesized for sensing intracellular pH. This probe showed excellent water solubility, it was sensitive toward the pH range from 4 to 12, and it was especially sensitive in alkaline environments. During the pH changes from acidic to alkaline environments, the color of the solution turned from yellow to purple, thus the difference in color can be used to distinguish between acidic and alkaline systems. The other major features of probe pH-DCN including high selectivity, low toxicity, good reversibility and stability allowed pH-DCN to visualize fluctuations of the pH in live cells. Moreover, probe pH-DCN has successfully discriminated cancer cells from normal cells by monitoring their different intracellular pH levels.

Deploying external bandwidth guaranteed media server clusters for real-time live streaming in media cloud

PLOS ONE

Authors: Zhang, Weizhan; He, Zhichao; Du, Biao; Luo, Minnan; Zheng, Qinghua

Abstract

The cloud-based media streaming service is a promising paradigm for multimedia applications. It is attractive to media streaming service providers, who wish to deploy their media server clusters in a media cloud at reduced cost. Since the real-time live streaming service is both a bandwidth-intensive and quality-sensitive application, how to optimize the internal bandwidth utilization of a data center network (DCN) as well as guarantee the external bandwidth of the real-time live streaming application, is a key issue of deploying virtual machine (VM)-hosted media server cluster in a media cloud. Therefore, in this study, we propose an external-bandwidth-guaranteed media server cluster deployment scheme in media cloud. The approach simultaneously considers the outside bandwidth requirement of a tree-based media server cluster for live streaming and the intra-bandwidth consumption of a DCN. The proposed scheme models the optimal problem as a new terminal-Steiner-tree-like problem and provides an approximate algorithm for placing the media servers. Our evaluation results show that the proposed scheme guarantees the external bandwidth requirement of a real-time live streaming application, at the same time, greatly reduces the intra-bandwidth utilization of a media cloud with different DCN structures.