Synthetic Human DPM2 blocking peptide for Apuri, BL, ELISA
Blocking/Immunizing peptide for anti-DPM2 antibody
For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not for human or animal consumption.
Shipped at ambient temperature, store at -20°C.
Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. The protein encoded by this gene is a hydrophobic protein that contains 2 predicted transmembrane domains and a putative ER localization signal near the C terminus. This protein associates with DPM1 in vivo and is required for the ER localization and stable expression of DPM1 and also enhances the binding of dolichol-phosphate to DPM1.
contributes_to dolichyl-phosphate beta-D-mannosyltransferase activity; protein binding;
DPM2; dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit; dolichol phosphate-mannose biosynthesis regulatory protein; MGC21559; MGC111193; dolichol phosphate-mannose synthase 2; FLJ80013;