Bovine DNA Topoisomerase I (DAG4857)

Bovine DNA Topoisomerase I, natural protein Datasheet

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Product Overview
Native bovine DNA Topoisomerase I (Scl-70)
Nature
Native
Tag/Conjugate
Unconjugated
Purity
SDS-PAGE (purity > 70%); Western blot with Scleroderma positive patient sera.
Concentration
0.5-0.8 μg/ml (depending on the type of ELISA plate and coating buffer). Suitable for labeling of functional groups.
Storage
2-8°C short term, -20°C long term
Antigen Description
DNA toposisomerase I is a key nuclear enzyme that interconverts supercoiled DNA to the required topological conformations for normal DNA replication and transcription. This enzyme is the target antigen for the so-called Scl-70 autoantibodies. Scl-70 antibodies are a specific marker in scleroderma patients (specificity 98-100%) and are associated with the presence of diffuse skin involvement and pulmonary fibrosis.
In human tissues the DNA topoisomerase I is initially synthesized as a protein with a molecular weight of 100 kDa. Most of this precursor is then proteolytically processed to a 70-kDa size, from which the Scl-70 antigen has derived its name
Keywords
topoisomerase (DNA) I; 11986; Ensembl:ENSG00000198900; DNA topoisomerase 1; type I DNA topoisomerase; 5.99.1.2; TOP1; TOPI

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