Batch dependent - please inquire should you have specific requirements
Preservative
None
Storage
2-8°C short term, -20°C long term
Introduction
DNA topoisomerase I is a key nuclear enzyme that interconverts supercoiled DNA to the required topological conformations for normal DNA replication and transcription. This enzyme is the target antigen for the so-called Scl-70 autoantibodies. Scl-70 antibodies are a specific marker in scleroderma patients (specificity 98-100%) and are associated with the presence of diffuse skin involvement and pulmonary fibrosis
Keywords
Scl-70; DNA topoisomerase I; Topo I; TOP1; Systemic sclerosis
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COA
Certificate of Analysis
