Human DFFB blocking peptide (DAG-P1506)

Synthetic Human DFFB blocking peptide for BL, WB

Nature
Synthetic
Tag/Conjugate
Unconjugated
Sequence Similarities
Contains 1 CIDE-N domain.
Cellular Localization
Cytoplasm. Nucleus.
Procedure
None
Format
Liquid
Buffer
PBS with 0.1% BSA 0.02% sodium azide pH7.2
Preservative
0.02% Sodium Azide
Storage
Shipped at 4°C. After reconstitution store at -20℃. Avoid freeze / thaw cycles. PBS with 0.1% BSA 0.02% sodium azide pH7.2
UniProt ID
Antigen Description
Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of some of these variants has not been determined. [provided by RefSeq, Sep 2013]
Function
DNA binding; deoxyribonuclease activity; enzyme binding; nicotinate phosphoribosyltransferase activity;
Synonyms
DFFB; DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase); CAD; CPAN; DFF2; DFF40; DFF-40; DNA fragmentation factor subunit beta; caspase-activated DNase; caspase-activated nuclease; caspase-activated deoxyribonuclease; DNA fragmentation factor 40 kDa subunit;

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References


Aoyama, T; Takemura, G; et al. Molecular mechanisms of non-apoptosis by Fas stimulation alone versus apoptosis with an additional actinomycin D in cultured cardiomyocytes. CARDIOVASCULAR RESEARCH 55:787-798(2002).
Lee, HJ; Lee, HS; et al. Tumor specificity and in vivo targeting of an antibody against exon 9 deleted E-cadherin in gastric cancer. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 133:987-994(2007).

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