Human DDR2 peptide

Name: Human DDR2 peptide
SKU: DAG-P1499
Rating: 5 (1 reviews)

Synthetic Human DDR2 peptide

COA

SDS

Datasheet

Summary

Specificity

The major 10 kDa transcript is expressed in high levels in heart and lung, less in brain, placenta, liver, skeletal muscle, pancreas, and kidney.

Nature

Synthetic

Tag/Conjugate

Unconjugated

SequenceSimilarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.Contains 1 F5/8 type C domain.Contains 1 protein kinase domain.

Purity

70 - 90% by HPLC.

Format

Liquid

Preservative

None

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. Information available upon request.

Entrez Gene ID

4921

Antigen Description

Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5 UTR results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

Function

ATP binding; collagen binding; protein binding; protein tyrosine kinase collagen receptor activity; transmembrane receptor protein tyrosine kinase activity;

Synonyms

DDR2; discoidin domain receptor tyrosine kinase 2; TKT; MIG20a; NTRKR3; TYRO10; discoidin domain-containing receptor 2; tyrosylprotein kinase; hydroxyaryl-protein kinase; discoidin domain receptor 2; tyrosine-protein kinase TYRO10; CD167 antigen-like family member B; cell migration-inducing protein 20; migration-inducing gene 16 protein; receptor protein-tyrosine kinase TKT; discoidin domain receptor family, member 2; neurotrophic tyrosine kinase receptor related 3; neurotrophic tyrosine kinase, receptor-related 3; discoidin domain-containing receptor tyrosine kinase 2;

Citations

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Documents

pdf COA

pdf SDS

pdf Datasheet

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Customer Reviews

References

Comprehensive investigation of clinicopathologic features, oncogenic driver mutations and immunohistochemical markers in peripheral lung squamous cell carcinoma

JOURNAL OF THORACIC DISEASE

Authors: Zhang, Yang; Zheng, Difan; Li, Yuan; Pan, Yunjian; Sun, Yihua; Chen, Haiquan

Abstract

Background: Although the majority of lung squamous cell carcinomas (SQCC) arise in central airways, the prevalence of peripheral (p) SQCC is increasing. This study aimed to have a comprehensive investigation of clinicopathologic features, status of common driver mutations and immunophenotypes of p-SQCC compared to central (c) SQCC. Methods: A total of 261 p-SQCC were compared to 444 c-SQCC for clinicopathologic characteristics. Comprehensive mutational analysis of EGFR, KRAS, HER2, BRAF, PIK3CA, DDR2, AKT1, ALK, ROS1, RET and FGFRs were performed. TTF1, CK7, Napsin A and PE10 protein expression were analyzed through immunohistochemistry (IHC). TTF1, CK7, CK8, SPA and TP63 gene expression levels were measured by quantitative real-time PCR. Results: Compared to c-SQCC, p-SQCC were associated with female (14.2% vs. 4.5%, P<0.001), never-smokers (22.6% vs. 13.3%, P=0.001), older age at diagnosis (64.9 vs. 59.5 years, P<0.001) and lower pathologic stage (P<0.001). The frequency of EGFR mutations was significantly higher in p-SQCC than c-SQCC (6.2% vs. 2.2%, P=0.040). Positive protein expression of TTF1 (P=0.010) and CK7 (P=0.001) was significantly more prevalent in p-SQCC. p-SQCC had significantly higher gene expression of SPA (P=0.003), whereas c-SQCC showed higher gene expression of TP63 (P=0.028). Conclusions: Lung p-SQCC had distinctive clinicopathologic characteristics and molecular features compared to c-SQCC, but showed some similarity with adenocarcinoma (ADC).

Simulation Methodology of DDR2 Interface with TI Processor and Timing Verification in HyperLynx

PROCEEDINGS OF 2019 16TH INTERNATIONAL BHURBAN CONFERENCE ON APPLIED SCIENCES AND TECHNOLOGY (IBCAST)

Authors: Shah, Syeda Hina

Abstract

This paper discusses about the Pre-layout and Post-layout simulations methodology of DDR2 interface present between TMS3206455 (Microprocessor from Texas Instruments) and MT47H64M16 (DDR2 memory from Micron) of the controller card. Simulations have been performed in HyperLynx software. Simulation models used such as IBIS models, its validation and generated controller timing model for simulation is also discussed. Interface signals are simulated in LineSim which is Pre-layout simulation tool of HyperLynx software. Also described in this paper the constraints of signals which have been developed at the pre layout stage and ensures the proper timing of data, strobe, mask, address, control and command signals. The constraints are then exported to BoardSim which is used for Post-layout simulations. BoardSim Simulation results show the correlation with LineSim results and validate the timing between selected processor and DDR2 memory.