Magic™ Anti-D240 monoclonal antibody, clone E3-41

Solvents used to clean oxygen system components must be assessed for oxygen compatibility because incompatible residue or fluid inadvertently left behind within an oxygen system can pose a flammability risk. The most recent approach focused on solvent ignition susceptibility to assess the flammability risk associated with these materials. Previous evaluations included ambient pressure liquid oxygen (LOX) mechanical impact testing (ASTM G86) and autogenous ignition temperature (AIT) testing (ASTM G72). The goal in this approach was to identify a solvent material that was not flammable in oxygen. As environmental policies restrict the available options of acceptable solvents, it has proven difficult to identify one that is not flammable in oxygen. A more rigorous oxygen compatibility approach is needed in an effort to select a new solvent for NASA applications. NASA's White Sands Test Facility proposed an approach that acknowledges oxygen flammability yet selects solvent materials based on their relative oxygen compatibility ranking, similar to that described in ASTM G63-99. Solvents are selected based on their ranking with respect to minimal ignition susceptibility, damage, and propagation potential, as well as their relative ranking when compared with other solvent materials that are successfully used in oxygen systems. Based on these comparisons, in which solvents exhibited properties within those ranges seen with proven oxygen system materials, it is believed that Solstice PF, L-14780, and Vertrel MCA would perform well with respect to oxygen compatibility.

Background: Lymphangioma circumscriptum (LC) is a benign lesion of lymphatic origin. Vulvar involvement occurs in various clinical settings. Methods: We present 12 cases, and compare lesions in patients with Crohn's disease and those associated with pelvic radiation. Results: The average age at presentation was 49 years. Thirty-three percent of the patients had Crohn's disease, 58% had radiation therapy and 9% had no significant medical history. Sixty-seven percent of the patients had multifocal lesions in anatomically distinct regions. Patients presented on average 16 years after onset of predisposing factors. Presenting complaints were pruritus, wetness and vulvar edema. Lesions were clinically heterogeneous, often found on the labia majora. Lesions consisted of dilated lymphatic channels at the junction of the reticular and papillary dermis. The cells lining these spaces lacked cytologic atypicality or mitotic activity. All lesions so examined were immunoreactive for D240. Patients were most often treated with surgical excision followed by laser ablation. Four of twelve patients, all with radiation-associated lesions, experienced disease progression necessitating additional surgery. Conclusions: Patients with LC secondary to radiation, when compared to those with Crohn's disease, were 10 years younger, more likely to have associated co-morbidities, and frequently experienced disease progression needing additional surgeries. Acquired vulvar LC has multiple causes with differing prognosis.