Product Overview
Blocking/Immunizing peptide for anti-Cystatin 8 (aa 100-112) antibody
Target
Cystatin 8 (aa 100-112)
Tag/Conjugate
Unconjugated
Application Notes
For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not for human or animal consumption.
Format
Lyophilized powder
Storage
Shipped at ambient temperature, store at -20°C.
Antigen Description
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a protein similar to type 2 cystatins. The encoded protein exhibits highly tissue-specific expression in the reproductive tract, suggesting implicit roles in reproduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Function
cysteine-type endopeptidase inhibitor activity;
Synonyms
CST8; cystatin 8 (cystatin-related epididymal specific); CRES; CTES5; cystatin-8; cystatin-related epididymal spermatogenic protein;
Citations
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Mishra, P; Qiu, Q; et al. In Vitro Regulatory Effect of Epididymal Serpin CRES on Protease Activity of Proprotein Convertase PC4/PCSK4. CURRENT MOLECULAR MEDICINE 12:1050-1067(2012).
Parent, AD; Cornwall, GA; et al. Alterations in the Testis and Epididymis Associated With Loss of Function of the Cystatin-Related Epididymal Spermatogenic (CRES) Protein. JOURNAL OF ANDROLOGY 32:444-463(2011).