Anti-idiotypic antibodies are antibodies directed against the complementarity determining regions (CDRs) (idiotype) of other antibodies or T cell receptors (TCRs). Anti-idiotype antibodies are key reagents in preclinical research such as pharmacokinetic (PK), pharmacodynamic (PD), Tox and immunogenicity studies. Typically, anti-idiotype antibodies are also deployed as positive controls in anti-drug antibody (ADA) assays . What is more, anti-idiotype antibodies that against receptors, like TCRs, can specifically bind and/or block their ligand-binding sites, facilitating the study of the structure and function of those receptors.
Creative Diagnostics offers highly specific anti-idiotype antibodies to meet your research needs. Besides, we provide a comprehensive suite of anti-idiotype antibody generation services, concerning development of both polyclonal and monoclonal anti-idiotype antibodies.