CASP9 blocking peptide (DAG-P1383)

Synthetic CASP9 blocking peptide for WB, BL Datasheet

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Specificity
Ubiquitous, with highest expression in the heart, moderate expression in liver, skeletal muscle, and pancreas. Low levels in all other tissues. Within the heart, specifically expressed in myocytes.
Nature
Synthetic
Tag/Conjugate
Unconjugated
Sequence Similarities
Belongs to the peptidase C14A family.Contains 1 CARD domain.
Format
Liquid
Buffer
Preservative: 0.02% Thimerosal (merthiolate) Constituents: 0.1% BSA, PBS, pH 7.2
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. Preservative: 0.02% Thimerosal (merthiolate) Constituents: 0.1% BSA, PBS, pH 7.2
UniProt ID
Antigen Description
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
Function
SH3 domain binding; cysteine-type endopeptidase activity; enzyme activator activity; peptidase activity; protein binding; protein kinase binding;
Synonyms
CASP9; caspase 9, apoptosis-related cysteine peptidase; MCH6; APAF3; APAF-3; PPP1R56; ICE-LAP6; caspase-9; apoptotic protease MCH-6; ICE-like apoptotic protease 6; apoptotic protease activating factor 3; protein phosphatase 1, regulatory subunit 56;

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