Mouse CASP12 blocking peptide (CDBP0688)

Synthetic Mouse CASP12 blocking peptide for BL

Product Overview
Caspase 12 ( N - term ) peptide ( mouse )
Target
Caspase 12
Nature
Synthetic
Species Reactivity
Mouse
Tag/Conjugate
Unconjugated
Procedure
None
Concentration
0.2 mg/ml
Size
50 μg
Buffer
PBS with 0.1% BSA 0.02% sodium azide pH7.2
Preservative
0.02% Sodium Azide
Storage
Upon Receipt - Keep as concentrated solution. Aliquot and store at -20℃ or below. Avoid freeze-thaw cycles.
UniProt ID
Antigen Description
Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Feb 2011]
Function
cysteine-type endopeptidase activity;
Synonyms
CASP12; caspase 12 (gene/pseudogene); CASP-12; CASP12P1; inactive caspase-12; caspase 12 pseudogene 1;

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References


Geiben-Lynn, R; Frimpong-Boateng, K; et al. Modulation of Plasmid DNA Vaccine Antigen Clearance by Caspase 12 RNA Interference Potentiates Vaccination. CLINICAL AND VACCINE IMMUNOLOGY 18:533-538(2011).

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