Anti-CTNNBL1 monoclonal antibody (DMABT-H13537)

Mouse anti-Human CTNNBL1 monoclonal antibody for WB, IHC, IF, sELISA, ELISA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG3
Clone
6G2
Species Reactivity
Human
Immunogen
CTNNBL1 (AAH36739, 210 a.a. ~ 311 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Target


Alternative Names
CTNNBL1; catenin, beta like 1; C20orf33, chromosome 20 open reading frame 33; beta-catenin-like protein 1; FLJ21108; NAP
Entrez Gene ID
UniProt ID

Product Background


Gene summary
CTNNBL1 (Catenin Beta Like 1) is a Protein Coding gene. Diseases associated with CTNNBL1 include auditory agnosia and sleep disorder. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway. GO annotations related to this gene include binding and enzyme binding. The protein encoded by this gene is a component of the pre-mRNA-processing factor 19-cell division cycle 5-like (PRP19-CDC5L) protein complex, which activates pre-mRNA splicing and is an integral part of the spliceosome. The encoded protein is also a nuclear localization sequence binding protein, and binds to activation-induced deaminase and is important for antibody diversification. This gene may also be associated with the development of obesity. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been defined on the X chromosome.
Antigen Description
Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR). May induce apoptosis. Beta-catenin-like protein 1 is a protein that in humans is encoded by the CTNNBL1 gene. 0The function about CTNNBL1 antigen include enzyme binding; protein binding.
Pathway
Spliceosome, organism-specific biosystem; Spliceosome, conserved biosystem; Spliceosome, Prp19/CDC5L complex, organism-specific biosystem.

Citations


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References


Conticello, SG; Ganesh, K; et al. Interaction between anti body-diversification enzyme AID and spliceosome-associated factor CTNNBL1. MOLECULAR CELL 31:474-484(2008).
Ganesh, K; Adam, S; et al. CTNNBL1 Is a Novel Nuclear Localization Sequence-binding Protein That Recognizes RNA-splicing Factors CDC5L and Prp31. JOURNAL OF BIOLOGICAL CHEMISTRY 286:17091-17102(2011).

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