Anti-CSNK1D monoclonal antibody (DMABT-H13521)

Mouse anti-Human CSNK1D monoclonal antibody for WB, IHC, IF, sELISA, ELISA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Clone
5I9
Species Reactivity
Human
Immunogen
CSNK1D (AAH03558,402a.a. ~ 415 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Target


Alternative Names
CSNK1D; casein kinase 1, delta; casein kinase I isoform delta; CKID; CKIdelta; HCKID
Entrez Gene ID
UniProt ID

Product Background


Gene summary
CSNK1D (Casein Kinase 1 Delta) is a Protein Coding gene. Diseases associated with CSNK1D include advanced sleep-phase syndrome, familial, 2 and advanced sleep phase syndrome. Among its related pathways are Gene Expression and Transport to the Golgi and subsequent modification. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CSNK1G2. This gene is a member of the casein kinase I (CKI) gene family whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein may also be involved in the regulation of apoptosis, circadian rhythm, microtubule dynamics, chromosome segregation, and p53-mediated effects on growth. The encoded protein is highly similar to the mouse and rat CK1 delta homologs. Three transcript variants encoding different isoforms have been found for this gene.
Antigen Description
Advanced sleep phase syndrome, familial, 2 (FASPS2) [MIM:615224]: A disorder characterized by very early sleep onset and offset. Individuals are morning larks with a 4 hours advance of the sleep, temperature and melatonin rhythms. Note=The disease is caused by mutations affecting the gene represented in this entry. The CSNK1D gene encodes the casein kinase I isoform delta enzyme in humans. 0The function about CSNK1D antigen include ATP binding; nucleotide binding; protein binding; protein kinase activity; protein kinase activity; protein kinase activity; protein serine/threonine kinase activity; tau-protein kinase activity.
Pathway
Canonical Wnt signaling pathway, organism-specific biosystem; Cell Cycle, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; Centrosome maturation, organism-specific biosystem; Circadian Clock, organism-specific biosystem; Circadian rhythm - mammal, organism-specific biosystem; Circadian rhythm - mammal, conserved biosystem.

Citations


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References


Kannanayakal, TJ; Mendell, JR; et al. Casein kinase 1 alpha associates with the tau-bearing lesions of inclusion body myositis. NEUROSCIENCE LETTERS 431:141-145(2008).
Peters, CA; Maizels, ET; et al. Induction of relaxin messenger RNA expression in response to prolactin receptor activation requires protein kinase C delta signaling. MOLECULAR ENDOCRINOLOGY 14:576-590(2000).

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