Anti-CLIC5 monoclonal antibody (DMABT-H13450)

Mouse anti-Human CLIC5 monoclonal antibody for WB, IHC, ELISA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Clone
2F7
Species Reactivity
Human
Immunogen
CLIC5 (NP_058625.2, 91 a.a. ~ 190 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Target


Alternative Names
CLIC5; chloride intracellular channel 5; chloride intracellular channel protein 5; MST130; MSTP130; FLJ90663
Entrez Gene ID
UniProt ID

Product Background


Gene summary
CLIC5 (Chloride Intracellular Channel 5) is a Protein Coding gene. Diseases associated with CLIC5 include deafness, autosomal recessive 103 and autosomal recessive non-syndromic sensorineural deafness type dfnb. Among its related pathways are Hepatic ABC Transporters and Neuropathic Pain-Signaling in Dorsal Horn Neurons. GO annotations related to this gene include chloride channel activity and voltage-gated chloride channel activity. An important paralog of this gene is CLIC1. This gene encodes a member of the chloride intracellular channel (CLIC) family of chloride ion channels. The encoded protein associates with actin-based cytoskeletal structures and may play a role in multiple processes including hair cell stereocilia formation, myoblast proliferation and glomerular podocyte and endothelial cell maintenance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Antigen Description
Deafness, autosomal recessive, 103 (DFNB103) [MIM:616042]: A form of sensorineural deafness with onset in early childhood. Hearing impairment progresses from mild to severe or even profound before the second decade, and is accompanied by vestibular areflexia. Note=The disease is caused by mutations affecting the gene represented in this entry. Chloride intracellular channel protein 5 is a protein that in humans is encoded by the CLIC5 gene. Chloride intracellular channels are involved in chloride ion transport within various subcellular compartments. CLIC5 specifically associates with the cytoskeleton of placenta microvilli. CLIC5 can form ion channel in bilayers and is regulated by actin. The function about CLIC5 antigen include protein binding; voltage-gated chloride channel activity; voltage-gated ion channel activity.

Citations


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References


Berryman, M; Bretscher, A; et al. Identification of a novel member of the chloride intracellular channel gene family (CLIC5) that associates with the actin cytoskeleton of placental microvilli. MOLECULAR BIOLOGY OF THE CELL 11:1509-1521(2000).
Shanks, RA; Larocca, MC; et al. AKAP350 at the Golgi apparatus - II. Association of AKAP350 with a novel chloride intracellular channel (CLIC) family member. JOURNAL OF BIOLOGICAL CHEMISTRY 277:40973-40980(2002).

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