General Notes
This product (Catalog No. CABT-BL1085) is a rabbit-derived polyclonal antibody raised against human CLIC3, targeting the amino acid region 1–236 of the protein. This antibody exhibits cross-reactivity with Human CLIC3 from mouse and rat. It has been affinity purified by Protein A. Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume (PMID: 9880541). CLIC3 (chloride intracellular channel protein 3) belongs to the chloride channel CLIC family which has seven members based on sequence homology to the p64 chloride channels of bovine kidney microsomes. CLIC proteins lack the membrane-spanning domains characteristic of channel proteins and are largely intracellular. CLIC3 is predominantly localized in the nucleus and has a high expression level in placenta (PMID: 9880541; 17027078). It associates with the C-terminal of ERK7 and may participate in cellular growth control.
CABT-BL1085 is suitable for use in Western blot (WB) (1:1,000–1:6,000), IHC (1:50–1:500), IF/ICC (1:10–1:100) applications.
CABT-BL1085 is supplied as a liquid formulation in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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