Anti-CKAP2 monoclonal antibody (DMABT-H13443)

Mouse anti-Human CKAP2 monoclonal antibody for WB, IHC, sELISA, ELISA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
4I2
Species Reactivity
Human
Immunogen
CKAP2 (AAH10901.1,2a.a. ~272a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Target


Alternative Names
CKAP2; cytoskeleton associated protein 2; cytoskeleton-associated protein 2; FLJ10749; LB1; se20 10
Entrez Gene ID
UniProt ID

Product Background


Gene summary
CKAP2 (Cytoskeleton Associated Protein 2) is a Protein Coding gene. Diseases associated with CKAP2 include inclusion conjunctivitis. An important paralog of this gene is CKAP2L. This gene encodes a cytoskeleton-associated protein that stabalizes microtubules and plays a role in the regulation of cell division. The encoded protein is itself regulated through phosphorylation at multiple serine and threonine residues. There is a pseudogene of this gene on chromosome 14. Alternative splicing results in multiple transcript variations.
Antigen Description
Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death in a p53/TP53-dependent manner (By similarity). Cytoskeleton-associated protein 2 is a protein that in humans is encoded by the CKAP2 gene.

Citations


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References


Kim, HS; Koh, JS; et al. Chromatin CKAP2, a New Proliferation Marker, as Independent Prognostic Indicator in Breast Cancer. PLOS ONE 9:-(2014).
Hong, KU; Choi, YB; et al. Transient phosphorylation of tumor associated microtubule associated protein (TMAP)/cytoskeleton associated protein 2 (CKAP2) at Thr-596 during early phases of mitosis. EXPERIMENTAL AND MOLECULAR MEDICINE 40:377-386(2008).

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