Anti-CFL2 monoclonal antibody (DMABT-H13419)

Mouse anti-Human CFL2 monoclonal antibody for WB, IHC, IF, sELISA, ELISA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
7H0
Species Reactivity
Human
Immunogen
CFL2 (NP_068733, 57 a.a. ~277a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Target


Alternative Names
CFL2; cofilin 2 (muscle); cofilin-2; cofilin, muscle isoform; NEM7
Entrez Gene ID
UniProt ID

Product Background


Gene summary
CFL2 (Cofilin 2) is a Protein Coding gene. Diseases associated with CFL2 include nemaline myopathy 7, autosomal recessive and typical congenital nemaline myopathy. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Regulation of actin cytoskeleton. GO annotations related to this gene include actin binding. An important paralog of this gene is DSTN. This gene encodes an intracellular protein that is involved in the regulation of actin-filament dynamics. This protein is a major component of intranuclear and cytoplasmic actin rods. It can bind G- and F-actin in a 1:1 ratio of cofilin to actin, and it reversibly controls actin polymerization and depolymerization in a pH-dependent manner. Mutations in this gene cause nemaline myopathy type 7, a form of congenital myopathy. Alternative splicing results in multiple transcript variants.
Antigen Description
Nemaline myopathy 7 (NEM7) [MIM:610687]: A form of nemaline myopathy. Nemaline myopathies are muscular disorders characterized by muscle weakness of varying severity and onset, and abnormal thread-like or rod-shaped structures in muscle fibers on histologic examination. Nemaline myopathy type 7 presents at birth with hypotonia and generalized weakness. Major motor milestones are delayed, but independent ambulation is achieved. Note=The disease is caused by mutations affecting the gene represented in this entry. Cofilin 2 (muscle) also known as CFL2 is a protein which in humans is encoded by the CFL2 gene. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. Cofilin-2 is a member of the AC group of proteins that also includes cofilin-1 (CFL1) and destrin (DSTN), all of which regulate actin-filament dynamics. The CFL2 gene encodes a skeletal muscle-specific isoform localized to the thin filaments, where it exerts its effect on actin, in part through interactions with tropomyosins. The function about CFL2 antigen include actin binding; protein binding.
Pathway
Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem; Caspase cascade in apoptosis, organism-specific biosystem; Fc gamma R-mediated phagocytosis, organism-specific biosystem; Fc gamma R-mediated phagocytosis, conserved biosystem; G13 Signaling Pathway, organism-specific biosystem; Pertussis, organism-specific biosystem.

Citations


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References


Kuramitsu, Y; Wang, YF; et al. Malignant Progressive Tumor Cell Clone Exhibits Significant Up-regulation of Cofilin-2 and 27-kDa Modified Form of Cofilin-1 Compared to Regressive Clone. ANTICANCER RESEARCH 33:3661-3665(2013).

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