Rabbit Anti-Human CEP78 (center) Polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

KLH-conjugated synthetic peptide encompassing a sequence within the center region of human CEP78.

Conjugate

Application Notes

WB:1:500-1:1000
IHC: 1:50-1:100

General Notes

This product (Catalog No. CABT-BL1049) is a rabbit-derived polyclonal antibody raised against human CEP78. It has been affinity purified by Protein A. This gene encodes a centrosomal protein that is both required for the regulation of centrosome-related events during the cell cycle, and required for ciliogenesis. The encoded protein has an N-terminal leucine-rich repeat (LRR) domain with six consecutive LRR repeats, and a C-terminal coiled-coil domain. It interacts with the N-terminal catalytic domain of polo-like kinase 4 (PLK4) and colocalizes with PLK4 to the distal end of the centriole. Naturally occurring mutations in this gene cause defects in primary cilia that result in retinal degeneration and sensorineural hearing loss which are associated with cone-rod degeneration disease as well as Usher syndrome. Low expression of this gene is associated with poor prognosis of colorectal cancer patients.
CABT-BL1049 is suitable for use in Western blot (WB) (1:500–1:1,000), IHC (1:50–1:100) applications.
CABT-BL1049 is supplied as a liquid formulation in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Alternative Names

C9orf81; Centrosomal protein of 78 kDa; Cep78

Entrez Gene ID

UniProt ID