Human CDNF blocking peptide (CDBP0750)

Synthetic Human CDNF blocking peptide for BL

Product Overview
Blocking peptide for anti-CDNF antibody
Target
CDNF
Nature
Synthetic
Species Reactivity
Human
Tag/Conjugate
Unconjugated
Application Notes
For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not suitable for human or animal consumption.
Procedure
None
Format
Liquid
Concentration
200 μg/ml
Size
50 μg
Buffer
PBS containing 0.02% sodium azide
Preservative
0.02% Sodium Azide
Storage
Store at -20℃, stable for one year.
UniProt ID
Antigen Description
CDNF (cerebral dopamine neurotrophic factor) is a protein-coding gene. Diseases associated with CDNF include cocaine dependence, and cerebritis. GO annotations related to this gene include growth factor activity. An important paralog of this gene is MANF.
Function
growth factor activity;
Synonyms
CDNF; cerebral dopamine neurotrophic factor; arginine rich, mutated in early stage tumors like 1 , ARMETL1; conserved dopamine neurotrophic factor; ARMET-like protein 1; arginine-rich, mutated in early stage tumors-like 1; ARMETL1;

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References


Unconventional neurotrophic factors CDNF and MANF: Structure, physiological functions and therapeutic potential

NEUROBIOLOGY OF DISEASE

Authors: Lindahl, Maria; Saarma, Mart; Lindholm, Paivi

Cerebral dopamine neurotrophic factor (CDNF) and mesencephalic astrocyte-derived neurotrophic factor (MANF) promote the survival of midbrain dopaminergic neurons which degenerate in Parkinson's disease (PD). However, CDNF and MANF are structurally and functionally clearly distinct from the classical, target-derived neurotrophic factors (NTFs) that are solely secreted proteins. In cells, CDNF and MANF localize in the endoplasmic reticulum (ER) and evidence suggests that MANF, and possibly CDNF, is important for the maintenance of ER homeostasis. MANF expression is particularly high in secretory tissues with extensive protein production and thus a high ER protein folding load. Deletion of MANF in mice results in a diabetic phenotype and the activation of unfolded protein response (UPR) in the pancreatic islets. However, information about the intracellular and extra cellular mechanisms of MANF and CDNF action is still limited. Here we will discuss the structural motifs and physiological functions of CDNF and MANF as well as their therapeutic potential for the treatment of neurodegenerative diseases and diabetes. Currently available knockout models of MANF and CDNF in mice, zebrafish and fruit fly will increase information about the biology of these interesting proteins. (C) 2016 Elsevier Inc. All rights reserved.

Cerebral dopamine neurotrophic factor (CDNF) levels are increased in bipolar disorder

BIPOLAR DISORDERS

Authors: Sehmbi, M.; Siddiqui, A.; Terpstra, K.; Mishra, R. K.; Frey, B. N.

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