Human CDNF blocking peptide (CDBP0749)

Synthetic Human CDNF blocking peptide for BL, WB

Product Overview
Blocking peptide for anti-CDNF antibody
Target
CDNF
Nature
Synthetic
Species Reactivity
Human
Tag/Conjugate
Unconjugated
Application Notes
For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not suitable for human or animal consumption.
Procedure
None
Format
Liquid
Concentration
200 μg/ml
Size
50 μg
Buffer
PBS containing 0.02% sodium azide
Preservative
0.02% Sodium Azide
Storage
Store at -20℃, stable for one year.
UniProt ID
Antigen Description
CDNF (cerebral dopamine neurotrophic factor) is a protein-coding gene. Diseases associated with CDNF include cocaine dependence, and cerebritis. GO annotations related to this gene include growth factor activity. An important paralog of this gene is MANF.
Function
growth factor activity;
Synonyms
CDNF; cerebral dopamine neurotrophic factor; arginine rich, mutated in early stage tumors like 1 , ARMETL1; conserved dopamine neurotrophic factor; ARMET-like protein 1; arginine-rich, mutated in early stage tumors-like 1; ARMETL1;

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References


Advanced sensing materials based on molecularly imprinted polymers towards developing point-of-care diagnostics devices

PROCEEDINGS OF THE ESTONIAN ACADEMY OF SCIENCES

Authors: Kidakova, Anna; Reut, Jekaterina; Boroznjak, Roman; Opik, Andres; Syritski, Vitali

Today there is growing interest in the replacement of biological receptors in biosensing systems including point-of-care (PoC) diagnostics devices due to their high price and short shelf life. Molecularly imprinted polymers (MIPs), which are wholly synthetic materials with antibody-like ability to bind and discriminate between molecules, demonstrate improved stability and reduced fabrication cost as compared with biological receptors. Here we report, for the first time, a MIP-based synthetic receptor capable of selective binding of a clinically relevant protein - the brain-derived neurotrophic factor (BDNF). The BDNF-MIP was generated by surface-initiated controlled/living radical photopolymerization directly on a screen-printed electrode (SPE). The resulting BDNF-MIP/SPE electrochemical sensor could detect BDNF down to 6 pg/mL in the presence of the interfering HSA protein and was capable of discriminating BDNF among its structural analogues, i.e. neurotropic factors CDNF and MANF. We believe that the presented approach for the preparation of a neurotrophic factor-selective sensor could be a promising route towards the development of innovative PoC diagnostics devices for the early-stage diagnostics and/or monitoring the therapy of neurological diseases.

Association analysis between polymorphisms in the conserved dopamine neurotrophic factor (CDNF) gene and cocaine dependence

NEUROSCIENCE LETTERS

Authors: Lohoff, Falk W.; Bloch, Paul J.; Ferraro, Thomas N.; Berrettini, Wade H.; Pettinati, Helen M.; Dackis, Charles A.; O'Brien, Charles P.; Kampman, Kyle M.; Oslin, David W.

Cocaine-induced neuroplasticity changes in the mesocorticolimbic dopamine systems are thought to be involved in the pathophysiology of cocaine dependence. Since neurotrophic factors have been observed to prevent/reverse and mimic cocaine-induced neurobiological changes in the brain, related genes are plausible candidates for susceptibility to cocaine dependence. The novel conserved dopamine neurotrophic factor protein (CDNF) promotes the survival, growth, and function of dopamine-specific neurons and is expressed in brain regions that undergo cocaine-induced neuroplasticity. In this study, we hypothesize that polymorphisms in the CDNF gene (CDNF/ARMETL1) contribute to increased risk for cocaine dependence. Cocaine dependent individuals (n = 351) and unaffected controls (n = 257) of African descent were ere genotyped for four single nucleotide polymorphisms (SNPs) in the CDNF gene (rs11259365, rs7094179, rs7900873. rs2278871). We observed no significant differences in allele, genotype, or haplotype frequencies between cases and controls for any of the tested SNPs. Our study suggests that there is no association between variants in the CDNF gene and cocaine dependence. However, additional studies using larger sample sizes, comprehensive SNP coverage, and clinically homogenous populations are necessary before confidently excluding CDNF as a significant genetic risk factor for cocaine dependence. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

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