Anti-CAPNS1 monoclonal antibody (DMABT-H12564)

Mouse anti-Human CAPNS1 monoclonal antibody for WB, IHC, IF, sELISA, ELISA, RNAi Knockdown Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
4D5
Species Reactivity
Human, Rat
Immunogen
CAPNS1 (AAH00592,283a.a. ~ 260 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Target


Alternative Names
CAPNS1; calpain, small subunit 1; CAPN4; calpain small subunit 1; 30K; CANP
Entrez Gene ID
UniProt ID

Product Background


Gene summary
CAPNS1 (Calpain Small Subunit 1) is a Protein Coding gene. Diseases associated with CAPNS1 include chronic neutrophilic leukemia. Among its related pathways are Degradation of the extracellular matrix and Integrin Pathway. GO annotations related to this gene include calcium ion binding and calcium-dependent cysteine-type endopeptidase activity. An important paralog of this gene is CAPNS2. This gene is a member of the calpain small subunit family. Calpains are calcium-dependent cysteine proteinases that are widely distributed in mammalian cells. Calpains operate as heterodimers, comprising a specific large catalytic subunit (calpain 1 subunit in Calpain I, and calpain 2 subunit in Calpain II), and a common small regulatory subunit encoded by this gene. This encoded protein is essential for the stability and function of both calpain heterodimers, whose proteolytic activities influence various cellular functions including apoptosis, proliferation, migration, adhesion, and autophagy. Calpains have been implicated in neurodegenerative processes, such as myotonic dystrophy. A pseudogene of this gene has been defined on chromosome 1. Alternative splicing results in multiple transcript variants.
Antigen Description
Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Calpain small subunit 1, also known as CAPN4, is a protein that in humans is encoded by the CAPNS1 gene. This gene encodes a small subunit common to both calpain I and II and is associated with myotonic dystrophy.
Pathway
Integrin-mediated cell adhesion, organism-specific biosystem.

Citations


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References


Ozaki, T; Tomita, H; et al. Characteristics of mitochondrial calpains. JOURNAL OF BIOCHEMISTRY 142:365-376(2007).
De Maria, A; Shi, YR; et al. Calpain Expression and Activity during Lens Fiber Cell Differentiation. JOURNAL OF BIOLOGICAL CHEMISTRY 284:13542-13550(2009).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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