Human CAPN6 blocking peptide (CDBP0671)

Synthetic Human CAPN6 blocking peptide for BL

Product Overview
Blocking peptide for anti-CAPN6 antibody
Target
CAPN6
Nature
Synthetic
Species Reactivity
Human
Tag/Conjugate
Unconjugated
Application Notes
For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not suitable for human or animal consumption.
Procedure
None
Format
Liquid
Concentration
200 μg/ml
Size
50 μg
Buffer
PBS containing 0.02% sodium azide
Preservative
0.02% Sodium Azide
Storage
Store at -20℃, stable for one year.
UniProt ID
Antigen Description
Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is highly expressed in the placenta. Its C-terminal region lacks any homology to the calmodulin-like domain of other calpains. The protein lacks critical active site residues and thus is suggested to be proteolytically inactive. The protein may play a role in tumor formation by inhibiting apoptosis and promoting angiogenesis. [provided by RefSeq, Nov 2009]
Function
calcium-dependent cysteine-type endopeptidase activity; microtubule binding;
Synonyms
CAPN6; calpain 6; CANPX; CAPNX; CalpM; DJ914P14.1; calpain-6; calpamodulin; calpain-like protease X-linked;

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References


Liu, NM; Yokota, T; et al. Transcription Profiles of Endothelial Cells in the Rat Ductus Arteriosus during a Perinatal Period. PLOS ONE 8:-(2013).
Lee, SJ; Choi, YL; et al. Increased expression of calpain 6 in uterine sarcomas and carcinosarcomas: an immunohistochemical analysis. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER 17:248-253(2007).

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