DFFB blocking peptide (DAG-P0423)

Synthetic DFFB blocking peptide for BL, WB Datasheet

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Nature
Synthetic
Tag/Conjugate
Unconjugated
Cellular Localization
Cytoplasmic and Nuclear
Format
Liquid
Buffer
PBS with 0.1% BSA 0.02% sodium azide pH7.2
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. PBS with 0.1% BSA 0.02% sodium azide pH7.2
UniProt ID
Antigen Description
Carbamoyl phosphate synthetase-aspartate carbamoyltransferase-dihydroorotase (CAD) is a multifunctional protein that initiates and regulates mammalian de novo pyrimidine biosynthesis. This trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis is the rate-limiting step in the de novo pyrimidine synthetic pathway. Although most of the CAD protein in the cell is cytosolic, phosphorylation at threonine 456 localizes the protein to the nucleus. While MAPK and EGF phosphorylate CAD at threonine 456, MAPK and c-myc have been found to induce over-expression of CAD.
Function
DNA binding; deoxyribonuclease activity; deoxyribonuclease activity; enzyme binding; hydrolase activity; nuclease activity; protein binding;
Synonyms
DFFB; DNA fragmentation factor, beta subunit; CAD; CPAN; 40kDa; DFF40; Didff; 5730477D02Rik; DNA fragmentation factor subunit beta; DFF-40; caspase-activated DNase; caspase-activated deoxyribonuclease; DNA fragmentation factor 40 kDa subunit; DNase inhibited by DNA fragmentation factor; DNA fragmentation factor, 40 kD, beta subunit;

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