Human C3c (DAGF-016)

Human C3c from normal human serum Datasheet

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Nature
Native
Tag/Conjugate
Unconjugated
Molecular Weight
139 kDa
Alternative Names
C3c
Purity
>90% by SDS-PAGE
Format
Liquid
Concentration
Batch dependent - please inquire should you have specific requirements.
Size
250 µg
Buffer
10 mM Sodium phosphate, 145 mM NaCl, pH 7.2
Storage
Store at -70°C or below. Avoid freeze/thaw.
Antigen Description
C3c is derived from iC3b (inactivated C3b) by proteolytic cleavage (Law, S.K.A. and Reid, K.B.M. (1995)). iC3b is created by cleavage of C3b by factor I in the presence of factor H, CR1 or MCP. C3c can be produced by an additional cleavage by factor I if the iC3b is bound to CR1. Factor H cannot serve as a cofactor for this cleavage. C3c can also be produced by the action of trypsin-like proteases on iC3b. If the C3b precursor was attached to a surface, then the iC3b will remain attached to that surface and when iC3b is cleaved the C3c is released into the surrounding solution while the C3dg/C3d fragment remains on that surface. The breakdown of fluid phase C3b is similar, but in this case both C3c and C3dg/C3d are soluble fragments.
Keywords
C3c

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