Tag/Conjugate
Unconjugated
Antigen Description
This gene encodes a serine/threonine-protein kinase that play a central role in mitosis. The encoded protein functions in part by phosphorylating members of the mitotic checkpoint complex and activating the spindle checkpoint. This protein also plays a role in inhibiting the activation of the anaphase promoting complex/cyclosome. This protein may also function in the DNA damage response. Mutations in this gene have been associated with aneuploidy and several forms of cancer. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Function
ATP binding; protein binding; protein kinase activity; protein serine/threonine kinase activity
Synonyms
BUB1; BUB1 mitotic checkpoint serine/threonine kinase; BUB1A; BUB1L; hBUB1; mitotic checkpoint serine/threonine-protein kinase BUB1; mitotic spindle checkpoint kinase; putative serine/threonine-protein kinase; budding uninhibited by benzimidazoles 1 homolog; BUB1 budding uninhibited by benzimidazoles 1 homolog
Citations
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Lee, H; et al. Impaired phosphorylation and mis-localization of Bub1 and BubR1 are responsible for the defective mitotic checkpoint function in Brca2-mutant thymic lymphomas. EXPERIMENTAL AND MOLECULAR MEDICINE 35:448-453(2003).
Simizu, S; Osada, H; et al. Mutations in the Plk gene lead to instability of Plk protein in human tumour cell lines. NATURE CELL BIOLOGY 2:852-854(2000).
COA
Certificate of Analysis
