Specificity
Ubiquitous. Widespread in normal smooth muscle tissue and neurons.
Tag/Conjugate
Unconjugated
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. Information available upon request.
Antigen Description
This gene encodes a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. This receptor associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system. Alternate start codons result in two isoforms of the protein. [provided by RefSeq, Jul 2008]
Function
bradykinin receptor activity; phosphatidylinositol phospholipase C activity; protease binding; protein binding; protein heterodimerization activity; type 1 angiotensin receptor binding;
Synonyms
BDKRB2; bradykinin receptor B2; B2R; BK2; BK-2; BKR2; BRB2; B2 bradykinin receptor; BK-2 receptor;
Citations
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Andrade, D; Serra, R; et al. Trypanosoma cruzi invades host cells through the activation of endothelin and bradykinin receptors: a converging pathway leading to chagasic vasculopathy. BRITISH JOURNAL OF PHARMACOLOGY 165:1333-1347(2012).
Lee, YJ; Zachrisson, O; et al. Upregulation of bradykinin B2 receptor expression by neurotrophic factors and nerve injury in mouse sensory neurons. MOLECULAR AND CELLULAR NEUROSCIENCE 19:186-200(2002).