Anti-BANF1 monoclonal antibody (DMABT-H13135)

Mouse anti-Human BANF1 monoclonal antibody for WB, IHC, sELISA, ELISA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Clone
4G20-5H23
Species Reactivity
Human
Immunogen
BANF1 (AAH05942,2a.a. ~ 89 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Target


Alternative Names
BANF1; barrier to autointegration factor 1; barrier-to-autointegration factor; BAF; breakpoint cluster region protein 1; NGPS
Entrez Gene ID
UniProt ID

Product Background


Gene summary
BANF1 (Barrier To Autointegration Factor 1) is a Protein Coding gene. Diseases associated with BANF1 include nestor-guillermo progeria syndrome and progeria. Among its related pathways are Regulation of Glucokinase by Glucokinase Regulatory Protein and HIV Life Cycle. An important paralog of this gene is BANF2. The protein encoded by this gene was first identified by its ability to protect retroviruses from intramolecular integration and therefore promote intermolecular integration into the host cell genome. The protein forms a homodimer which localizes to both the nucleus and cytoplasm and is specifically associated with chromosomes during mitosis. This protein binds to double stranded DNA in a non-specific manner and also binds to LEM-domain containing proteins of the nuclear envelope. This protein is thought to facilitate nuclear reassembly by binding with both DNA and inner nuclear membrane proteins and thereby recruit chromatin to the nuclear periphery. Alternative splicing results in multiple transcript variants encoding the same protein.
Antigen Description
Nestor-Guillermo progeria syndrome (NGPS) [MIM:614008]: An atypical progeroid syndrome characterized by normal development in the first years of life, later followed by the emergence of generalized lipoatrophy, severe osteoporosis, and marked osteolysis. The atrophic facial subcutaneous fat pad and the marked osteolysis of the maxilla and mandible result in a typical pseudosenile facial appearance with micrognathia, prominent subcutaneous venous patterning, a convex nasal ridge, and proptosis. Cognitive development is completely normal. Patients do not have cardiovascular dysfunction, atherosclerosis, or metabolic anomalies. Note=The disease is caused by mutations affecting the gene represented in this entry. Barrier-to-autointegration factor is a protein that in humans is encoded by the BANF1 gene. It is a member of the barrier-to-autointegration factor family of proteins. The protein encoded by this gene was identified by its ability to protect retroviruses from intramolecular integration and therefore promote intermolecular integration into the host cell genome. The endogenous function of the protein is unknown. The protein forms a homodimer which localizes to the nucleus and is specifically associated with chromosomes during mitosis. This protein binds to DNA in a non-specific manner and studies in rodents suggest that it also binds to lamina-associated polypeptide 2, a component of the nuclear lamina. It also associates with the LEM Domain containing proteins LAP2, Emerin, and MAN1. The function about BANF1 antigen include DNA binding.
Pathway
2-LTR circle formation, organism-specific biosystem; APOBEC3G mediated resistance to HIV-1 infection, organism-specific biosystem; Autointegration results in viral DNA circles, organism-specific biosystem; Disease, organism-specific biosystem; Early Phase of HIV Life Cycle, organism-specific biosystem; HIV Infection, organism-specific biosystem; HIV Life Cycle, organism-specific biosystem.

Citations


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References


Forne, I; Carrascal, M; et al. Identification of the autoantigen HB as the barrier-to-autointegration factor. JOURNAL OF BIOLOGICAL CHEMISTRY 278:50641-50644(2003).
Mansharamani, M; Graham, DRM; et al. Barrier-to-autointegration factor BAF binds p55 Gag and matrix and is a host component of human immunodeficiency virus type 1 virions. JOURNAL OF VIROLOGY 77:13084-13092(2003).

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