The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5-epsilon -- gamma-G -- gamma-A -- delta -- beta--3
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
Citations
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Abuljadayel, IS; Ahsan, T; et al. Infusion of autologous retrodifferentiated stem cells into patients with beta-thalassemia. THESCIENTIFICWORLDJOURNAL 6:1278-1297(2006).
Balmer, P; Phillips, HM; et al. The effect of nitric oxide on the growth of Plasmodium falciparum, P-chabaudi and P-berghei in vitro. PARASITE IMMUNOLOGY 22:97-106(2000).
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