Anti-ZYX (internal region) polyclonal antibody

Species Reactivity

Human

Immunogen

A synthetic peptide corresponding to amino acids at internal region of human ZYX. The sequence is C-QQREKPRVQEKQH

Conjugate

Application Notes

ELISA: 1:4000; WB: 0.1-0.3 μg/mL. & The optimal working dilution should be determined by the end user.

Alternative Names

ZYX; zyxin; ESP-2; HED-2; zyxin-2;

Entrez Gene ID

UniProt ID

Antigen Description

Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform.

Pathway

E-cadherin signaling in keratinocytes; Focal adhesion; Stabilization and expansion of the E-cadherin adherens junction;