Specifications
Species Reactivity
Mouse; Rat; Human
Immunogen
Synthetic peptide: PPQPREKVSSIDLEIDS conjugated to KLH by an N-terminal Cysteine residue linker, corresponding to amino acids 134-150 of Human Zyxin
Applications
Application Notes
WB: 1 - 2 μg/ml;
Target
Alternative Names
ZYX; zyxin; zyxin-2; ESP-2; HED-2;
Product Background
Antigen Description
Zyxin binds alpha-actinin and the CRP proteins and is implicated in the regulation and modulation of actin filaments organization, cell adhesion, cell motility, mitosis, and signal transduction. Zyxin may shuttle between focal adhesion plaques and the nucleus. It has been suggested that zyxin is involved in gene transcription by its association with transcription factors in the nucleus.
Pathway
E-cadherin signaling in keratinocytes, organism-specific biosystem; Focal Adhesion, organism-specific biosystem; Focal adhesion, organism-specific biosystem; Focal adhesion, conserved biosystem; Integrin-mediated cell adhesion, organism-specific biosystem; Stabilization and expansion of the E-cadherin adherens junction, organism-specific biosystem;
Citations
Publication ()
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COA
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