Anti-ZAP70 monoclonal antibody, clone 620DU9.2.3

Antibody Isotype

IgG1

Clone

620DU9.2.3

Species Reactivity

Human

Conjugate

Application Notes

WB: 1:100-500

Alternative Names

ZAP70; SRK; Tyrosine-protein kinase ZAP-70; 70 kDa zeta-chain associated protein; Syk-related tyrosine kinase

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes an enzyme belonging to the proteintyrosine kinase family, and it plays a role in T-cell developmentand lymphocyte activation. This enzyme, which is phosphorylated ontyrosine residues upon T-cell antigen receptor (TCR) stimulation,functions in the initial step of TCR-mediated signal transductionin combination with the Src family kinases, Lck and Fyn. Thisenzyme is also essential for thymocyte development. Mutations inthis gene cause selective T-cell defect, a severe combinedimmunodeficiency disease characterized by a selective absence ofCD8-positive T-cells. Two transcript variants that encode differentisoforms have been found for this gene.

Pathway

Adaptive Immune System; B Cell Receptor Signaling Pathway; Generation of second messenger molecules; Immune System; Inflammatory Response Pathway; Interferon type I; NF-kappa B signaling pathway; Natural killer cell mediated cytotoxicity;