Anti-Tadpole Optic Nerves monoclonal antibody (DMAB9370)

Mouse anti-Xenopus Tadpole Optic Nerves monoclonal antibody for IHC(PFA fixed) Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG3
Clone
5B9
Species Reactivity
Xenopus
Immunogen
Tadpole optic nerves, retinae from dounced fresh or frozen tissue.
Conjugate
Unconjugated

Target


Alternative Names
Tadpole optic nerves, retinae

Product Background


Antigen Description
ltrastructural evidence indicates that Xenopus retinal ganglion cell axons differentiate early, between stages 28 and 32. Light microscope studies indicated the presence of argryophilic material in the ventral retina and optic stalk of early embryos. Ultrastructural analysis of this region confirmed the presence of axons in the stalk and interstices of ventral retinal cells. Axons containing aligned microtubules and neurofilaments and elongated mitochondria with a paucity of other cell inclusions are found with increasing frequency in the ventral retina from stages 28 through. Central and dorsal regions of the retinas examined show little or no evidence of axons. A discrete, small bundle of axons is found in the optic stalk of stage 28 embryos and by stage the number of axons in bundles has increased, suggesting early fasciculation. Between stages 28 and (± 12 hr) extracellular space surrounding early axons diminishes and processes from neuroretinal cells in contact with axons surround developing axon bundles. The evidence presented suggests that axon initiation occurs in stages much earlier than previously reported. Other investigators have failed to detect ganglion cell differentiation prior to stage 32 possibly because they examined regions of the retina with few axons. Thus, experiments which rotate the retina in the orbit may have to be reevaluated since regenerating axons may use previously established pathways to organize and "home in" on tectal target cells.

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