Anti-XPO4 polyclonal antibody (DPABH-05184)

Rabbit anti-Human XPO4 (N-terminal) polyclonal antibody for WB, IHC-P, IHC-Fr Datasheet

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Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Mouse, Rat, Human
Immunogen
A synthetic peptide from the N terminal region of human Exportin 4 conjugated to an immunogenic carrier protein
Conjugate
Unconjugated

Applications


Application Notes
WB: 1/300 - 1/2000; IHC-P: 1/300 - 1/2000; IHC-Fr: 1/300 - 1/2000.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
XPO4; exportin 4; exp4; exportin-4
Entrez Gene ID
UniProt ID

Product Background


Gene summary
XPO4 (Exportin 4) is a Protein Coding gene. Diseases associated with XPO4 include conjunctival degeneration and pinguecula. Among its related pathways are Ran Pathway. GO annotations related to this gene include binding. XPO4 belongs to a large family of karyopherins (see MIM 602738) that mediate the transport of proteins and other cargo between the nuclear and cytoplasmic compartments (Lipowsky et al. , 2000 [PubMed 10944119]).
Antigen Description
Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO4 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Exportin-4 is a protein that in humans is encoded by the XPO4 gene. 0The function about XPO4 antigen include protein binding.

Citations


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References


Belin, BJ; Mullins, RD; et al. What we talk about when we talk about nuclear actin. NUCLEUS-AUSTIN 4:291-297(2013).
Nalaskowski, MM; Windhorst, S; et al. Subcellular localisation of human inositol 1,4,5-trisphosphate 3-kinase C: species-specific use of alternative export sites for nucleo-cytoplasmic shuttling indicates divergent roles of the catalytic and N-terminal domains. BIOLOGICAL CHEMISTRY 387:583-593(2006).

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