Rabbit Anti-Human XPO4 Polyclonal Antibody for WB
XPO4 (Exportin 4) is a Protein Coding gene. Diseases associated with XPO4 include conjunctival degeneration and pinguecula. Among its related pathways are Ran Pathway. GO annotations related to this gene include binding. XPO4 belongs to a large family of karyopherins (see MIM 602738) that mediate the transport of proteins and other cargo between the nuclear and cytoplasmic compartments (Lipowsky et al. , 2000 [PubMed 10944119]).
Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO4 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Exportin-4 is a protein that in humans is encoded by the XPO4 gene. 0The function about XPO4 antigen include protein binding.
Nalaskowski, MM; Windhorst, S; et al. Subcellular localisation of human inositol 1,4,5-trisphosphate 3-kinase C: species-specific use of alternative export sites for nucleo-cytoplasmic shuttling indicates divergent roles of the catalytic and N-terminal domains. BIOLOGICAL CHEMISTRY 387:583-593(2006).
Tsuchiya, M; Ogawa, H; et al. Exportin 4 Interacts with Sox9 through the HMG Box and Inhibits the DNA Binding of Sox9. PLOS ONE 6:-(2011).
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.