Specifications
Species Reactivity
Human; Dog; Mouse; Rat
Immunogen
Synthetic peptide sequence C-GRGHNTRTEKRKEK from the internal region of Wnt-3 (NP_110380.1).
Applications
Application Notes
ELISA: 1/16,000; Immunohistology - Paraffin: 3.0 - 5.0ug/ml; Western Blot: 1.0 - 3.0ug/ml
Target
Alternative Names
WNT3; wingless-type MMTV integration site family, member 3; INT4; proto-oncogene Wnt-3; WNT-3 proto-oncogene protein; proto-oncogene Int-4 homolog
Product Background
Antigen Description
Wnt-3, otherwise known as Int-4, is involved in cell fate decisions and patterning during embryogenesis, cell signalling during neural tube development, and implicated in the tumorogenesis of several cancers including breast, lung, hepatocellular(HCC), and gastric carcinoma.
Pathway
AMPK inhibits chREBP transcriptional activation activity; AMPK signaling; Adipocytokine signaling pathway; BDNF signaling pathway; Circadian rhythm; Corticotropin-releasing hormone; Energy Metabolism; Energy dependent regulation of mTOR by LKB1-AMPK; Fatty acid, triacylglycerol, and ketone body metabolism; FoxO signaling pathway; Hypertrophic cardiomyopathy (HCM); IGF1R signaling cascade; IRS-mediated signalling; IRS-related events; IRS-related events triggered by IGF1R; Import of palmitoyl-CoA
Citations
Publication ()
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COA
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