Anti- type 3 T3D Monoclonal antibody (DMAB9356)

Mouse Anti- type 3 T3D Monoclonal antibody for IP, WB, IHC Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Species Reactivity
Virus
Immunogen
Type 3 dearing from mammalian orthoreovirus, seroptype 3 prototype strain of virus, isolated from a human child in mid-1950s.
Conjugate
Unconjugated

Target


Alternative Names
Respiratory Enteric Orphan Virus; T3D; Type 3 Dearing

Product Background


Gene summary
CD3D (CD3d Molecule) is a Protein Coding gene. Diseases associated with CD3D include immunodeficiency 19 and t-b+ severe combined immunodeficiency due to cd3delta/cd3epsilon/cd3zeta. Among its related pathways are Immune System and G-protein signaling_Regulation of RAC1 activity. GO annotations related to this gene include protein heterodimerization activity and transmembrane signaling receptor activity. An important paralog of this gene is CD3G. The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined.
Antigen Description
Immunodeficiency 19 (IMD19) [MIM:615617]: An autosomal recessive form of severe combined immunodeficiency characterized by onset in early infancy of recurrent bacterial, viral, and fungal infections. Patients usually have chronic diarrhea, recurrent respiratory infections, and failure to thrive. Immunologic work-up shows a T-cell negative, B-cell positive, NK-cell positive phenotype. Note=The disease is caused by mutations affecting the gene represented in this entry. Severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T(-)B(+)NK(+) SCID) [MIM:608971]: A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development. T-cell surface glycoprotein CD3 delta chain is a protein that in humans is encoded by the CD3D gene. 0Reoviridae is a family of viruses that can affect the gastrointestinal system (such as Rotavirus) and respiratory tract. Viruses in the family Reoviridae have genomes consisting of segmented, double-stranded RNA (dsRNA). The name "Reoviridae" is derived from respiratory enteric orphan viruses. The term "orphan virus" means that a virus that is not associated with any known disease. Even though viruses in the Reoviridae family have more recently been identified with various diseases, the original name is still used. Reovirus infection occurs often in humans, but most cases are mild or subclinical. The virus can be readily detected in feces, and may also be recovered from pharyngeal or nasal secretions, urine, cerebrospinal fluid, and blood. Despite the ease of finding Reovirus in clinical specimens, their role in human disease or treatment is still uncertain.

Citations


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References


Mbisa, JL; Becker, MM; et al. Reovirus mu 2 protein determines strain-specific differences in the rate of viral inclusion formation in L929 cells. VIROLOGY 272:16-26(2000).
HALLER, BL; BARKON, ML; et al. BRAIN-SPECIFIC AND INTESTINE-SPECIFIC VARIANTS OF REOVIRUS SEROTYPE-3 STRAIN DEARING ARE SELECTED DURING CHRONIC INFECTION OF SEVERE COMBINED IMMUNODEFICIENT MICE. JOURNAL OF VIROLOGY 69:3933-3937(1995).

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