Anti-Verotoxin II A subunit monoclonal antibody (DMAB4509)

Mouse anti-Verotoxin II A subunit monoclonal antibody for ELISA, Neut Datasheet

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Host Species
Antibody Isotype
Species Reactivity
Purified toxoid


Alternative Names
rRNA N glycosidase; Shiga like toxin II subunit A; SLT IIA; Verotoxin 2 subunit A; Verotoxin II – A subunit (SLT-2a), Shiga-like; SLT-2a

Product Background

Antigen Description
Shiga-like toxin, alsoknown as verotoxin, is a toxin generated by some strains of Escherichia coli(but see below). It is named for its similarity to the AB5-type Shiga toxinproduced by the bacteria Shigella dysenteriae. There are two types, known asSLT1 and SLT2. Verotoxin II/SLT 2a belongs to theribosome-inactivating protein family. The shiga-like toxins contain a singleA subunit and multiple copies of a B subunit. The A subunit is responsiblefor inhibiting protein synthesis through the catalytic inactivation of 60Sribosomal subunits. Catalytic activity comprises the endohydrolysis of theN-glycosidic bond at one specific adenosine on the 28S rRNA. Suitable for use in ELISA and Neutralization. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.


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