Specifications
Immunogen
A synthetic peptide of human VPS36 is used for rabbit immunization.
Target
Alternative Names
VPS36; vacuolar protein sorting 36 homolog (S. cerevisiae); C13orf9, chromosome 13 open reading frame 9 , vacuolar protein sorting 36 homolog (yeast); vacuolar protein-sorting-associated protein 36; CGI 145; Eap45; ELL-associated protein, 45 kDa; ESCRT-II
Product Background
Antigen Description
Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3.
Pathway
ESCRT-II complex, organism-specific biosystem; Endocytosis, organism-specific biosystem; Endocytosis, conserved biosystem; Endosomal Sorting Complex Required For Transport (ESCRT), organism-specific biosystem; Membrane Trafficking, organism-specific biosy
Citations
Publication ()
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COA
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