Anti-VPS25 (aa 116-144) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Mouse

Immunogen

Synthetic peptide conjugated to KLH, corresponding to a region within C terminal amino acids 116-144 of Human VPS25 (UniProt ID: Q9BRG1).

Conjugate

Application Notes

WB: 1/100 - 1/500.

Alternative Names

VPS25; vacuolar protein sorting 25 homolog (S. cerevisiae); vacuolar protein sorting 25 (yeast); vacuolar protein-sorting-associated protein 25; DERP9; EAP20; MGC10540; ESCRT-II complex subunit VPS25; ELL-associated protein of 20 kDa; dermal papilla-deriv

Entrez Gene ID

UniProt ID

Antigen Description

Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. The ESCRT-II complex may be involved in facilitating the budding of certain RNA viruses.

Pathway

ESCRT-II complex; Endocytosis; Endosomal Sorting Complex Required For Transport (ESCRT); Membrane Trafficking;