Anti-VDAC1 monoclonal antibody, clone FQS21963(C)

Antibody Isotype

IgG

Clone

FQS21963(C)

Species Reactivity

Mouse; Rat; Human

Immunogen

Synthetic peptide, corresponding to aresidues near the N-terminus of Human VDAC1 (Uniprot ID P21796).

Conjugate

Application Notes

WB: 1/1000 - 1/10000; IHC-P: 1/100 - 1/250.

Alternative Names

VDAC1; voltage-dependent anion channel 1; voltage-dependent anion-selective channel protein 1; MGC111064; PORIN; porin 31HL; porin 31HM; plasmalemmal porin; outer mitochondrial membrane protein porin 1; VDAC-1;

Entrez Gene ID

UniProt ID

Antigen Description

Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.

Pathway

Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; HTLV-I infection, organism-specific biosystem; HTLV-I infection, conserved biosystem; Huntingtons disease, organism-specific biosystem; Huntingtons disease, conserved biosystem; Influenza A, organism-specific biosystem;