Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitement by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly.
Pathway
B cell receptor signaling pathway; Cell death signalling via NRAGE, NRIF and NADE; Chemokine signaling pathway; Coregulation of Androgen receptor activity; EGFR1 Signaling Pathway;
Citations
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