Anti-VAMP3 monoclonal antibody, clone l3B3

Antibody Isotype

IgG2b

Clone

l3B3

Species Reactivity

Human; Mouse

Immunogen

Recombinant protein corresponding to amino acids 1-77 of human VAMP3.

Conjugate

Alternative Names

VAMP3; vesicle-associated membrane protein 3 (cellubrevin); vesicle-associated membrane protein 3; CEB; VAMP-3; cellubrevin; synaptobrevin-3;

Entrez Gene ID

UniProt ID

Antigen Description

Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Because of its high homology to other known VAMPs, its broad tissue distribution, and its subcellular localization, the protein encoded by this gene was shown to be the human equivalent of the rodent cellubrevin. In platelets the protein resides on a compartment that is not mobilized to the plasma membrane on calcium or thrombin stimulation.

Pathway

Arf6 trafficking events, organism-specific biosystem; Phagosome, organism-specific biosystem; Phagosome, conserved biosystem; SNARE interactions in vesicular transport, organism-specific biosystem; SNARE interactions in vesicular transport, conserved biosystem;