Anti-V beta 5.1 TCR monoclonal antibody (DMAB24638)

Mouse anti-Human V beta 5.1 TCR monoclonal antibody for FC, FuncS Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
MD5
Species Reactivity
Human
Conjugate
Unconjugated

Target


Alternative Names
T cell receptor Vbeta5.1 allele; Mouse Anti-V beta 5.1 TCR Monoclonal Antibody; Anti-V beta 5.1 TCR Monoclonal Antibody; V beta 5.1 TCR Monoclonal Antibody Mouse Anti-V beta 5.1 TCR MAb; Anti-V beta 5.1 TCR MAb; V beta 5.1 TCR MAb

Product Background


Antigen Description
This monoclonal antibody recognizes the human T cell receptor (TCR) Vbeta5. 1 allele. Composed of an alpha and beta chain, TCR specificity is typically determined by Vaalpha, Jalpha, Vbeta, Dbeta, and Jbeta gene rearrangement. Vbeta expression in humans has been examined in studies on the effects of superantigens, inflammation, autoimmune disease, and HIV infection. More recently, assessment of TCR Vbeta expression has been used to phenotype T cell clonality in CD3+/TCRalphabeta+ large granular lymphocyte leukemias. A member of the Ig superfamily, this receptor is expressed on a subset of peripheral blood T cells.

Citations


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References


Dummer, R; Heald, PW; et al. Sezary syndrome T-cell clones display T-helper 2 cytokines and express the accessory factor-1 (Interferon-gamma receptor beta-chain). BLOOD 88:1383-1389(1996).
CHRISTMAS, SE; BREW, R; et al. HUMAN T-CELLS EXPRESSING V-BETA-8 DO NOT PREDOMINANTLY RECOGNIZE DR2 ALLOANTIGEN. IMMUNOLOGY 76:192-196(1992).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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