UNC13B (NP_006368, 1482 a.a. ~ 1591 a.a) partial recombinant protein with GST tag. The sequence is SKSNNWAPKYNETFHLLLGNEEGPESYELQICVKDYCFAREDRVLGLAVMPLRDVTAKGS CACWCPLGRKIHMDETGLTILRILSQRSNDEVAREFVKLKSESRSTEEGS
Conjugate
Unconjugated
Target
Alternative Names
UNC13B; unc-13 homolog B (C. elegans); UNC13; MUNC13; Unc13h2; protein unc-13 homolog B; munc13-2; homolog of rat Munc13 (diacylglycerol-binding);
This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis.
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